UC San Diego School of Biological Sciences
Department of Neurobiology

Blumenstock, S., Arakelyan, D., del Grosso, N., Schneider, S., Shao, Y., Gjoni, E., Klein, R., Dudanova, I., and Komiyama, T. (2026)
Restoring cortical disinhibition improves Huntington’s disease phenotypes (PDF)
Nature https://www.nature.com/articles/s41586-026-10671-9

Wright, W. J., Chen, E. C.-Y., Zhou, B., Wang, J., Liu, Z., Morales, B. C., and Komiyama, T. (2026)
Local plasticity underlies the reorganization of cortical circuit dynamics during motor learning (PDF)
Current Biology https://www.sciencedirect.com/science/article/pii/S0960982226005877

Gjoni, E., Sristi, R. D., Liu, H., Dror, S., Lin, X., O’Neil, K., Arroyo, O. M., Hong, S. W., Kim, H., Liu, J., Blumenstock, S., Lim, B., Mishne, G., and Komiyama, T. (2026)
“Complementary cortical and thalamic contributions to cell type–specific striatal activity dynamics during movement” (PDF)
Science Advances https://www.science.org/doi/10.1126/sciadv.aea3935

Ramot, A., Taschbach, F. H., Yang, Y. C., Hu, Y., Chen, Q., Morales, B. C., Wang, X. C., Wu, A., Tye, K. M., Benna, M. K., and Komiyama, T. (2025)
“Motor learning refines thalamic influence on motor cortex.” (PDF)
Nature, https://www.nature.com/articles/s41586-025-08962-8

Blumenstock, S., Arakelyan, D., del Grosso, N., Schneider, S., Shao, Y., Gjoni, E., Klein, R., Dudanova, I., and Komiyama, T. (2025)
“Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington’s Disease mice” (PDF)
bioRxiv https://www.biorxiv.org/content/10.1101/2025.02.07.637155v1

Hwang, E.J., Link, T.D., Hu, Y.Y., Lu, S., Wang, E.H., Lilascharoen, V., Aronson, S., O’Neil, K., Lim, B.K., and Komiyama, T. (2019)
“Corticostriatal Flow of Action Selection Bias.” (PDF)
Neuron https://pubmed.ncbi.nlm.nih.gov/31706697/

Wu, A., Chen, Q., Yu, B., Chae, S., Tan, Z., Ramot, A., and Komiyama, T. (2025)
“Targeted stimulation of motor cortex neural ensembles drives learned movements” (PDF)
bioRxiv https://www.biorxiv.org/content/10.1101/2025.01.06.631504v1

Economo, M., Komiyama, T.*, Kubota, Y.*, and Shiller, J.* (2024)
“Learning and control in motor cortex across cell types and scales.” (Review) (PDF)
Journal of Neuroscience, 44 (40) e1233242024;https://www.jneurosci.org/content/44/40/e1233242024

Hedrick, N.G., Wright, J. William., and Komiyama, T. (2024)
“Local and global predictors of synapse elimination during motor learning.” (PDF)
Science Advances, https://www.science.org/doi/epdf/10.1126/sciadv.adk0540.

Dunton, K.L.*, Hedrick, N.G.*, Meamardoost, S., Ren, C., Howe, J.R., Wang, J., Root, C.M., Gunawan, R., Komiyama, T.#, Zhang, Y.#, Hwang, E.J.# (2024)
“Divergent learning-related transcriptional states of cortical glutamatergic neurons.” (PDF)
Journal of Neuroscience, https://doi.org/10.1523/JNEUROSCI.0302-23.2023.

Meamardoost, S., Bhattacharya, M., Hwang, E.J., Ren, C., Wang, L., Mewes, C., Zhang, Y., Komiyama, T., and Gunawan, R. (2023),
“Rewiring Dynamics of Functional Connectome in Motor Cortex during Motor Skill Learning.” (PDF)
Data Science in Science, 2(1)
Preprint at https://www.biorxiv.org/content/10.1101/2022.07.12.499746v1

Hedrick, N.G., Lu, Z., Bushong, E., Singhi, S., Nguyen, P., Magaña, Y., Jilani, S., Lim, B.K., Ellisman, M., and Komiyama, T. (2022)
“Learning binds new inputs into functional synaptic clusters via spinogenesis” (PDF)
Nature Neuroscience https://www.nature.com/articles/s41593-022-01086-6

Ren, C., Peng, K., Yang, R., Liu, W., Liu, C., and Komiyama, T. (2022)
“Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning” (PDF)
Neuron https://www.cell.com/neuron/fulltext/S0896-6273(24)00358-1

Hwang, E.J.*, Dahlen, J.E.*, Mukundan, M., and Komiyama, T. (2021)
“Disengagement of motor cortex during long-term learning tracks the performance level of learned movements.” (PDF)
Journal of Neuroscience https://www.jneurosci.org/content/41/33/7029

Ma, Z., Liu, H., Komiyama, T., and Wessel, R. (2020)
“Stability of layer-specific motor cortex network states during learning-associated neural reorganizations.” (PDF)
Journal of Neurophysiology https://journals.physiology.org/doi/full/10.1152/jn.00061.2020

Hwang, E.J., Link, T.D., Hu, Y.Y., Lu, S., Wang, E.H., Lilascharoen, V., Aronson, S., O’Neil, K., Lim, B.K., and Komiyama, T. (2019)
“Corticostriatal Flow of Action Selection Bias.” (PDF)
Neuron https://pubmed.ncbi.nlm.nih.gov/31706697/

Hwang, E.J., Dahlen, J.E., Hu, Y.Y., Aguilar, K., Yu, B., Mukundan, M., Mitani, A., and Komiyama, T. (2019)
“Disengagement of motor cortex from movement control during long-term learning.” (PDF)
Science Advances https://www.science.org/doi/10.1126/sciadv.aay0001

Peters, A.J., Lee, J., Hedrick, N.G., O’Neil, K., and Komiyama, T. (2017)
“Reorganization of corticospinal output during motor learning.” (PDF)
Nature Neuroscience https://www.nature.com/articles/nn.4596

Makino, H.*#, Ren, C.*, Liu, H.*, Kim, A.N., Kondapaneni, N., Liu, X., Kuzum, D. and Komiyama, T.#(2017)
“Transformation of cortex-wide emergent properties during motor learning.” (PDF)
Neuron https://www.sciencedirect.com/science/article/pii/S0896627317303410?via%3Dihub

Peters, A.J., Liu, H. and Komiyama, T. (2017)
“Learning in the rodent motor cortex.” (Review) (PDF)
Annual Review of Neuroscience https://www.annualreviews.org/content/journals/10.1146/annurev-neuro-072116-031407

Chen, S.X., Kim, A.N., Peters, A.J. and Komiyama, T. (2015)
“Subtype-specific Plasticity of Inhibitory Circuits During Motor Learning.” (PDF)
Nature Neuroscience https://www.nature.com/articles/nn.4049

    Peters, A.J., Chen, S.X. and Komiyama, T. (2014)
    “Emergence of Reproducible Spatiotemporal Activity During Motor Learning.” (PDF)
    Nature https://www.nature.com/articles/nature13235

    • Rated by Faculty of 1000.

      Komiyama, T.*, Sato, T.R., O’Connor, D.H., Zhang, Y.X., Huber, D., Hooks, B.M., Gabbito, M. and Svoboda, K. (2010)
      “Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice.” (PDF)
      Nature https://www.nature.com/articles/nature08897

      • Rated by Faculty of 1000.